Immune Microbx, 60 Caps

Immune Microbx, 60 Caps

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Immune – Microbx provides natural anti-microbial activity for colds, flu, respiratory, and digestive concerns.

Supports

  • Immunity – Colds, Flu, Respiratory Health and Allergies  
  • Digestion – Candida, Dysbiosis, H Pylori, and Parasites  
  • Inflammation – Respiratory, Digestive, and Brain Health 

Feature Ingredients

  • Grapefruit Seed Extract (GSE) is an antimicrobial and antioxidant made from the seeds and pulp of grapefruit. 
  • Other antimicrobial, antioxidant, and anti-inflammatory nutrients include goldenseal, oregano, thyme, Echinacea, rosemary and cat’s claw. 

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Immune – Microbx is a professionally formulated combination of nutraceuticals that have antimicrobial properties, and support immunity. 

  • Grapefruit seed extract (GSE) or citrus seed extract is a supplement made from the seeds and pulp of grapefruit. Grapefruit seed extract contains potent compounds that can kill more than 60 types of bacteria and yeast.1-4 Researchers concluded that GSE kills bacteria by breaking down their outer membranes, causing them to burst open after just 15 minutes of exposure.2 It kills yeast cells by causing apoptosis, a process in which cells self-destruct.4 Naringenin, is the active ingredient that is thought to be responsible for its antioxidant properties.5 Animal studies have also found that GSE can help digestive health by protecting the stomach from damage from alcohol and stress. In addition, it has been found to be effective in killing the bacteria H. pylori which is linked to stomach inflammation and ulcers.6,7 
  • Goldenseal has antimicrobial (antibacterial, antifungal) and anti-inflammatory activity.8,9 It seems to be effective for E coli, which can cause urinary tract infections and digestive problems leading to diarrhoea.8,9 In addition, it contains berberine which may be the active agent that helps to reduce blood sugar, lower cholesterol and improve digestive concerns.8,9 
  • Oregano has antimicrobial, antiviral and antifungal properties that have been shown in lab settings.10,11 In addition, compounds in oregano oil are also a potent antioxidant, anti-inflammatory, antidiabetic, and cancer-suppressor agents.10-13 Oregano may also help with indigestion, gastrointestinal, and respiratory illnesses. The primary antimicrobial properties are thought to be linked to the active ingredients carvacrol and thymol.14,15 Extracts of oil of oregano have been found to have antimicrobial and antioxidant activity in vitro against common microbes including E. coli, S. aureus,16,17 L. innocua and L. monocytogenes,18S. scerevisiae, A. niger,17 B. cereus, B. subtilis, C. albicans, Ei tenella,19  Blastocytis hominis, Entamoeba hartmanni, or Endolimax nana and improve overall symptoms.20-22 It is speculated that carvacrol and thymol are able to inhibit biofilm formation,23 disrupt the cell membrane of bacteria, and in particular, sensitize the phospholipid bilayer of the cell membrane, increasing the permeability and leakage of vital intracellular constituents. In addition, efflux pump inhibition is another proposed intracellular mechanism of action which can boost antimicrobial activity.24 
  • Thyme contains compounds like thymol and carvacrol (plant-based phenols) that have antioxidant, antimicrobial, antitussive, expectorant, antispasmodic and antibacterial effects.25-28 Thyme has been used to support immunity, respiratory infections, oral health, menstrual cramps, and topically for atopic dermatitis.29   
  • Echinacea contains flavonoids, cichoric acid and rosmarinic acid that contributes to its health benefits which include improved immunity, reduced inflammation, and ability to help lower blood sugar levels.30 A review of 14 studies found that it may lower the risk of developing colds by more than 50% and shorten the duration of colds by one and a half days.31 
  • Rosemary is known to have one of the highest antioxidant properties of spices and can combat fungus, bacteria, and cancer.32 Rosemary is rich in bioactive compounds including rosmarinic acid and carnosol which have antioxidant and anti-inflammatory activity.32 In addition, Rosemary contains carnosic acid and rosmarinic acid which support brain health, working memory, alertness, and information retrieval.33 
  • Cat's claw contains a compound known as pentacyclic oxindolic alkaloid (POA) that is believed to have anti-inflammatory effects.34 The compound, specific to cat's claw, is able to block the production of inflammatory substances such as tumour necrosis factor-alpha (TNF-alpha).34 TNF-a helps regulate the immune response and, among other things, is responsible for inducing fever, inflammation, and apoptosis (programmed cell death) in old or damaged cells. 

Be ready for colds and flu with our Professional Immune – Microbx support.  

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SKU: ; NPN:

Serving Size: 2 Vegetarian Capsules

Servings per Container: 60

Medicinal Ingredients

Each Vegetable Capsule Contains: 

Goldenseal (Hydrastis canadensis) root extract, 5% alkaloids 

100 mg  

Oregano (Organum vulgare) leaf/flower 

100 mg  

Thyme (Thymus vulgaris) leaf 

100 mg  

Grapefruit Seed Extract 4:1    

25 mg (equivalent to 100mg of dried product) 

Echinacea (Echinacea angustifolia) root 

16.7 mg (equivalent to 100mg of dried herb) 

Rosemary (Rosmarinus officinalis) leaf extract, 6% carnosic acid 

50 mg 

Cat's Claw (Uncaria Tormentosa), 20%  

30 mg  

Non-Medicinal Ingredients

GMO vegetarian capsules composed of vegetable hypromellose, and purified water.  

Allergens

Contains No:  Contains No: Added: corn, dairy,  eggs, fish, gluten, shellfish, animal products, salt, gluten, soy, tree nuts, or GMOs. Suitable for vegetarians/vegans. 

Recommended Use

Adults 19+: 2 capsule daily between meals, increase to 2x daily at the onset of cold/flu symptoms for 4-5 days or as directed by your health-care practitioner. Consult a health-care practitioner for use beyond 10 days.   

Revivelife Advantage

Immune Microbx provides researched nutraceuticals that have antimicrobial, antioxidant and anti-inflammatory action to support immunity for colds and flu. 

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Contraindications 

Do not use if you are hypersensitive or allergic to any of the ingredients (especially to the Lamiaceae family, which includes basil, mint, rosemary, sage, savory, marjoram, oregano, hyssop, thyme, lavender and perilla). Do not use if you are pregnant, breast-feeding, newborn babies, or in children.  

Caution 

Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition including but not limited to: autoimmune disorder, bleeding disorder, kidney, liver or gall bladder, disorder, diabetes, blood pressure problems or have a progressive systemic disease such as multiple sclerosis, AIDS and/or HIV infection. Discontinue 2 weeks prior to any scheduled surgery.  

Side Effect Risks 

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance, stomach upset or irritation, nausea, dizziness, changes in blood pressure or blood sugar 

Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place. 

Disclaimer  

The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.  

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References

  1. Heggers et al, The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J Altern Complement Med 2002 Jun; 8(3): 333-40 
  2. Reagor L, et al, The effectiveness of processed grapefruit-seed extract as an antibacterial agent: I. An in vitro agar assay., J Altern Complement Med 2002 Jun; 8(3):325-32 
  3. Cvetnic Z and Vladimir-Knezevic S, Antimicrobial activity of grapefruit seed and pulp ethanolic extract., Acta Pharm 2004 Sep; 54(3):243-50 
  4. Cao S, et al, A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast., PLoS One, 2012;7(3) 
  5. Salehi B, Fokou PVT, Sharifi-Rad M, et al. The Therapeutic Potential of Naringenin: A Review of Clinical Trials.   Pharmaceuticals (Basel). 2019;12(1):11. Published 2019 Jan 10.  
  6. Zayachkivska OS, et al, Gastroprotective effects of flavonoids in plant extracts., J Physiol Pharmacol 2005 Mar; 56 Suppl 1:219-31 
  7. Guzeldag G, et al, Preliminary Examination of Herbal Extracts on the Inhibition of Helicobacter Pylori, Afr J Tradit Complement Altern Med. 2014; 11(1): 93-96. – h pylori 
  8. Kevan A, et al, Goldenseal (Hydrastic canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition, Planta Med. 2011 May; 77(8):835-840  
  9. Chen C, et al, Effects of Berberine in the Gastrointestinal Tract - A Review of Actions and Therapeutic Implications, A J of Chin Med; 42(5) 1053-1070 
  10. Leyva-López, N.; Gutiérrez-Grijalva, E.P.; Vazquez-Olivo, G.; Heredia, J.B. Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties. Molecules 2017, 22, 989 
  11. Han F, et al, J Zhejiang Univ Sci B. 2017;18(1):79–84. Chemical composition and antioxidant activities of essential oils from different parts of the oregano.  
  12. Shen D, et al, J Agric Food Chem. 2010;58(12):7119–25. LC-MS method for the simultaneous quantitation of the anti-inflammatory constituents in oregano (Origanum species).  
  13. Orchard A, Van vuuren S. Commercial Essential Oils as Potent Antimicrobials to Treat Skin Diseases. Evid Based Complement Alternat Med. 2017;2017:4517971. doi:10.1155/2017/4517971 
  14. Guarda A, et al,  Int J Food Microbiol. 2011;146(2):144–50. The antimicrobial activity of microencapsulated thymol and carvacrol. 
  15. Nostro A, et al, Recent Pat Antiinfect Drug Discov. 2012;7(1):28–35. Antimicrobial activity of carvacrol: current progress and future prospectives.  
  16. Preuss H, et al, Toxicol Mech Methods. 2005;15(4):279–85. Effects of essential oils and monolaurin on Staphylococcus aureus: in vitro and in vivo studies.  
  17. de Barros J, et al, Braz J Microbiol. 2012;43(3):1120–7. Combination of Origanum vulgare L. essential oil and lactic acid to inhibit Staphylococcus aureus in meat broth and meat model. De Barros J, et al. 
  18. Teixeira B, et al, J Sci Food Agric. 2013;93(11):2707–14. Chemical composition and bioactivity of different oregano (Origanum vulgare) extracts and essential oil.  
  19. Bisht, D, et al, Nat Prod Res. 2011;25(20):1993–8. Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger.  
  20. Toulah F, et al, J Egypt Soc Parasitol. 2012;42(1):245–50. The efficacy of Origanum vulgare on Eimeria tenella.  
  21. Force M,et al, Phytother Res. 2000;14(3):213–4. Inhibition of enteric parasites by emulsified oil of oregano in vivo. 
  22. De Falco E, et al, Molecules. 2013;18(12):14948–60. Chemical composition and biological activity of essential oils of Origanum vulgare L. subsp. vulgare L. under different growth conditions. 
  23. Carezzano M, et al, Plant Biol (Stuttg). 2017;19(4):599–607. Inhibitory effect of Thymus vulgaris and Origanum vulgare essential oils on virulence factors of phytopathogenic Pseudomonas syringae strains. 
  24. Perrin E, et al, Future Microbiol. 2018;13:59–67. Antimicrobial activity of six essential oils against Burkholderia cepacia complex: insights into mechanism(s) of action.  
  25. Höferl M, Buchbauer G, Jirovetz L, et al. Correlation of antimicrobial activities of various essential oils and their main aromatic volatile constituents. Journal of Essential Oil Research. 2009;21(5):459–463.  
  26. Youdim KA, Damien Dorman HJ, Deans SG. The antioxidant effectiveness of thyme oil, α-tocopherol and ascorbyl palmitate on evening primrose oil oxidation. Journal of Essential Oil Research. 1999;11(5):643–648.  
  27. Barnes J, Anderson LA, Philipson JD. Herbal Medicines. 3rd edition. London, UK: Pharmaceutical Press; 2007.  
  28. Dorman HJD, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Journal of Applied Microbiology. 2000;88(2):308–316.  
  29. ESCOP. ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products. 2nd edition. The European Scientific Cooperative on Phytotherapy in collaboration with Georg Thieme; 2007.  
  30. Melchart D, et al, Immunomodulation with Echinacea – a systematic review of controlled clinical trials. , Phytomedicine 1994 Dec; 1(3):245-54 
  31. Shah SA, et al, Evaluation of Echinacea for the prevention and treatment of the common cold: a meta-analysis, Lancet Infect Dis 2007 Jul;&(7):473-80 
  32. Genna AK, et al, Rosemary (Rosmarinus officinalis) - a study of the composition, antioxidant and antimicrobial activities of extracts obtained with supercritical carbon dioxide, Food Science and Technology, 28 (2), April/June 2008 
  33. Penelly A, et al, Short-term study on the effects of rosemary on cognitive function in an elderly population. J Med Food. 2012 Jan; 15(1):10-7 
  34. Mur E, Hartig F, Eibl G, Schirmer M. Randomized double-blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol. 2002;29(4):678-81. 

 

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